Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504475 | 0.91 | KMT2A (0.62) | KMT2AMEN1PKMALDH1A1MAPT | |
| SCHEMBL30631460 | 0.82 | MEN1 (0.67) | KMT2AMEN1PKMALDH1A1MAPT | |
| SCHEMBL776014 | 0.82 | MEN1 (0.67) | KMT2AMEN1PKMALDH1A1MAPT | |
| SCHEMBL15445432 | 0.82 | KMT2A (0.64) | KMT2AMEN1PKMALDH1A1MAPT | |
| SCHEMBL29366579 | 0.81 | KMT2A (0.63) | KMT2AMEN1PKMALDH1A1MAPT | |
| SCHEMBL393627 | 0.81 | KMT2A (0.63) | KMT2AMEN1PKMALDH1A1MAPT | |
| SCHEMBL31312808 | 0.80 | KMT2A (0.62) | KMT2AMEN1PKMALDH1A1MAPT | |
| SCHEMBL20494881 | 0.80 | KMT2A (0.62) | KMT2AMEN1PKMALDH1A1MAPT | |
| SCHEMBL20495354 | 0.80 | KMT2A (0.62) | KMT2AMEN1PKMALDH1A1MAPT | |
| SCHEMBL437783 | 0.80 | KMT2A (0.67) | KMT2AMEN1PKMALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999006401-A1 | 2-ARYL-2,5-DIHYDRO-PYRAZOLO[4,3-c]QUINOLIN-3-ONES AS GABA ALPHA 5 RECEPTOR INVERSE AGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1999-02-11 | — | — | WO | disclosed |