Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 3/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 7/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3884874 | 0.86 | SRC (0.38) | SRCLRRK2PRKDCKDRPIK3CA | |
| SCHEMBL5507082 | 0.85 | SRC (0.35) | SRCLRRK2PRKDCKDRPIK3CA | |
| SCHEMBL13955657 | 0.84 | SRC (0.44) | SRCLRRK2PRKDCABCB1ABCC1 | |
| SCHEMBL3887019 | 0.80 | SRC (0.43) | SRCLRRK2EGFRERBB2RAF1 | |
| SCHEMBL3883564 | 0.80 | SRC (0.39) | SRCLRRK2PRKDCABCB1ABCC1 | |
| SCHEMBL3896435 | 0.77 | SRC (0.42) | SRCLRRK2EGFRRAF1MAP2K1 | |
| SCHEMBL3880256 | 0.76 | GABRA1 (0.36) | SRCLRRK2PRKDCABCB1ABCC1 | |
| SCHEMBL3879099 | 0.75 | SRC (0.43) | SRCKDREGFRERBB2RAF1 | |
| SCHEMBL3882562 | 0.75 | SRC (0.39) | SRCLRRK2PRKDCEGFRERBB2 | |
| SCHEMBL3891687 | 0.72 | GABRA1 (0.37) | SRCABCB1ABCC1ABCG2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771443-A1 | QUINOLINE THIAZOLINONES WITH CDK1 ANTIPROLIFERATIVE ACTIVITY | F.HOFFMANN-LA ROCHE AG (CH) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006002828-A1 | QUINOLINE THIAZOLINONES WITH CDK1 ANTIPROLIFERATIVE ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-12 | — | — | WO | disclosed |