Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3464226 | 0.78 | NISCH (0.33) | NISCHCHRNB2CHRNA4 | |
| SCHEMBL5508758 | 0.70 | CHRNB2 (0.32) | CHRNB2CHRNA4 | |
| SCHEMBL9557396 | 0.69 | HRH3 (0.44) | NISCHGSK3BDYRK1A | |
| SCHEMBL29891608 | 0.69 | HRH3 (0.44) | NISCHGSK3BDYRK1A | |
| Hydrochloric Acid SCHEMBL20744274 | 0.68 | HRH3 (0.43) | NISCHGSK3BDYRK1A | |
| SCHEMBL29506048 | 0.68 | NISCH (0.30) | NISCH | |
| SCHEMBL3954850 | 0.67 | CHEK1 (0.41) | NISCHGSK3BDYRK1ACHRNB2CHRNA4 | |
| SCHEMBL29889443 | 0.67 | CHEK1 (0.41) | NISCHGSK3BDYRK1ACHRNB2CHRNA4 | |
| SCHEMBL19116619 | 0.67 | CHEK1 (0.41) | NISCHGSK3BDYRK1ACHRNB2CHRNA4 | |
| SCHEMBL8271401 | 0.67 | CHEK1 (0.41) | NISCHGSK3BDYRK1ACHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802601-A1 | AZASPIROALKENE AND AZAPIROALKANE COMPOUNDS WITH NICOTINIC CHOLINERGIC RECEPTOR ACTIVITY | Targacept, Inc. (US) | 2007-07-04 | — | — | EP | claimed |
| WO-2006034089-A1 | AZASPIROALKENE AND AZASPIROALKANE COMPOUNDS WITH NICOTINIC CHOLINERGIC RECEPTOR ACTIVITY | TARGACEPT, INC. (US) | 2006-03-30 | — | — | WO | claimed |