Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2867677 | 0.78 | KCNH2 (0.47) | KCNH2NOS2S1PR1S1PR3PPARA | |
| SCHEMBL2682119 | 0.78 | FPR2 (0.46) | — | |
| SCHEMBL27854898 | 0.77 | — | — | |
| SCHEMBL14764837 | 0.77 | KCNH2 (0.37) | KCNH2S1PR1S1PR3PPARAALDH1A1 | |
| SCHEMBL3663915 | 0.74 | KCNH2 (0.39) | KCNH2S1PR1S1PR3PPARAALDH1A1 | |
| SCHEMBL15448352 | 0.73 | GCGR (0.44) | KCNH2TLR8S1PR1S1PR3ALDH1A1 | |
| SCHEMBL28341385 | 0.72 | KCNH2 (0.39) | KCNH2NOS2TLR8S1PR1S1PR3 | |
| SCHEMBL5544212 | 0.72 | KCNH2 (0.41) | KCNH2NOS2S1PR1S1PR3PPARA | |
| SCHEMBL5548022 | 0.70 | KCNH2 (0.43) | KCNH2S1PR1S1PR3PPARAALDH1A1 | |
| SCHEMBL544961 | 0.69 | KCNH2 (0.46) | KCNH2NOS2TLR8ALDH1A1TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758654-A1 | USE OF C-KIT INHIBITORS FOR TREATING PLASMODIUM RELATED DISEASES | AB Science (FR) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005102455-A1 | USE OF C-KIT INHIBITORS FOR TREATING PLASMODIUM RELATED DISEASES | AB SCIENCE (FR) | 2005-11-03 | — | — | WO | disclosed |