Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.64 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.64 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.64 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.64 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.64 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | RHOC | P08134 | 1/20 | 0.62 |
| ▸ | RHOA | P61586 | 1/20 | 0.62 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 3/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | BRAF | P15056 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13202441 | 0.90 | MAPT (0.70) | MAPTKCNK3LMNAP2RX1KCNQ3 | |
| SCHEMBL2498464 | 0.85 | KCNK3 (0.66) | MAPTKCNK3LMNAP2RX1KCNQ3 | |
| SCHEMBL30413950 | 0.84 | KDR (0.67) | MAPTLMNARAB9AMEN1HTT | |
| SCHEMBL665533 | 0.84 | KDR (0.67) | MAPTLMNARAB9AMEN1HTT | |
| SCHEMBL5131380 | 0.83 | RHOC (0.80) | MAPTKCNK3LMNAP2RX1KCNQ3 | |
| SCHEMBL2492831 | 0.83 | PTGS1 (0.70) | MAPTKCNK3LMNAP2RX1KCNQ3 | |
| SCHEMBL14468045 | 0.83 | MEN1 (0.68) | MAPTKCNK3LMNAP2RX1KCNQ3 | |
| SCHEMBL4286068 | 0.83 | MAPT (0.94) | MAPTKCNK3LMNAP2RX1KCNQ3 | |
| SCHEMBL2497820 | 0.82 | CSF1R (0.70) | MAPTKCNK3LMNAP2RX1KCNQ3 | |
| SCHEMBL2495539 | 0.81 | MAPT (0.61) | MAPTKCNK3LMNAP2RX1KCNQ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |
| US-20070054916-A1 | Aryl nitrogen-containing bicyclic compounds and methods of use | AMGEN INC. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054916-A1 | Aryl nitrogen-containing bicyclic compounds and methods of use | MAP3K1, MAP3K5, MAP3K2 | MAPT 4333/4885KCNK3 835/4885LMNA 1675/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.