Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CTSC | P53634 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5495854 | 0.94 | PDGFRB (0.52) | AURKASYKPDGFRBPDGFRAHDAC3 | |
| SCHEMBL10971409 | 0.78 | HDAC3 (0.59) | AURKASYKHDAC3HDAC1HDAC2 | |
| SCHEMBL5495932 | 0.77 | RAB9A (0.54) | PDGFRBPDGFRAGAANPC1RAB9A | |
| SCHEMBL5499638 | 0.76 | CYP2A6 (0.66) | PDGFRBPDGFRACYP2A6KDRCYP2E1 | |
| SCHEMBL5496551 | 0.76 | CTSC (0.44) | AURKASYKCYP2A6CTSCCYP2E1 | |
| SCHEMBL5502963 | 0.76 | CTSC (0.59) | SYKPDGFRBPDGFRACYP2A6CTSC | |
| SCHEMBL5502604 | 0.75 | SYK (0.54) | AURKASYKMAPTMAPK1 | |
| SCHEMBL5499768 | 0.75 | MAPT (0.44) | AURKASYKPDGFRBPDGFRACYP2A6 | |
| SCHEMBL13605374 | 0.74 | CDK4 (0.51) | KDR | |
| SCHEMBL7474268 | 0.73 | PIK3CA (0.65) | SYKKDRNPC1RAB9ACDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753750-A1 | THIOPHENE HETEROARYL AMINES | Sugen, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005113548-A1 | THIOPHENE HETEROARYL AMINES | SUGEN, INC. (US) | 2005-12-01 | — | — | WO | disclosed |