Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.68 |
| ▸ | MMP1 | P03956 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 1/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504693 | 1.00 | HDAC1 (0.68) | HDAC1HDAC8MMP1PTPN1GSK3B | |
| SCHEMBL5508790 | 0.98 | HDAC1 (0.65) | HDAC1HDAC8MMP1PTPN1GSK3B | |
| SCHEMBL5509133 | 0.93 | HDAC1 (0.62) | HDAC1HDAC8MMP1PTPN1GSK3B | |
| SCHEMBL4100412 | 0.85 | HDAC1 (0.69) | HDAC1HDAC8MMP1PTPN1GSK3B | |
| SCHEMBL739090 | 0.85 | HDAC1 (0.69) | HDAC1HDAC8MMP1PTPN1GSK3B | |
| SCHEMBL4259306 | 0.85 | HDAC1 (0.69) | HDAC1HDAC8MMP1PTPN1GSK3B | |
| SCHEMBL3381534 | 0.85 | HDAC1 (0.69) | HDAC1HDAC8MMP1PTPN1GSK3B | |
| SCHEMBL5849457 | 0.85 | HDAC1 (0.69) | HDAC1HDAC8MMP1PTPN1GSK3B | |
| SCHEMBL11873561 | 0.83 | NPC1 (0.51) | HDAC1HDAC8L3MBTL1MAPTLMNA | |
| SCHEMBL739420 | 0.83 | HDAC1 (0.68) | HDAC1HDAC8MMP1PTPN1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828161-A2 | PHENYLPIPERAZINES WITH A COMBINATION OF AFFINITY FOR DOPAMINE -D2 RECEPTORS AND SEROTONIN REUPTAKE SITES | Solvay Pharmaceuticals B.V. (NL) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006061372-A2 | PHENYLPIPERAZINES WITH A COMBINATION OF AFFINITY FOR DOPAMINE -D2 RECEPTORS AND SEROTONIN REUPTAKE SITES | SOLVAY PHARMACEUTICALS B.V. (NL) | 2006-06-15 | — | — | WO | disclosed |
| US-20060122177-A1 | Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | SOLVAY PHARMACEUTICALS B.V. | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122177-A1 | Phenylpiperazines with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites | HTR2A, HTR2C, HTR5A | HDAC1 3211/4885HDAC8 4093/4885MMP1 4609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.