Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 8/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6110943 | 0.81 | MAPT (0.40) | MAPTTSHRALDH1A1L3MBTL1CHEK2 | |
| SCHEMBL1623554 | 0.81 | CHEK2 (0.44) | MAPTTSHRALDH1A1L3MBTL1CHEK2 | |
| SCHEMBL1623550 | 0.81 | CHEK2 (0.44) | MAPTTSHRALDH1A1L3MBTL1CHEK2 | |
| SCHEMBL1623844 | 0.80 | ALDH1A1 (0.54) | MAPTTSHRALDH1A1L3MBTL1CHEK2 | |
| SCHEMBL1623846 | 0.80 | ALDH1A1 (0.54) | MAPTTSHRALDH1A1L3MBTL1CHEK2 | |
| SCHEMBL1083968 | 0.77 | NR1I2 (0.49) | MAPTTSHRALDH1A1L3MBTL1CHEK2 | |
| SCHEMBL1084083 | 0.77 | GBA1 (0.50) | MAPTTSHRALDH1A1L3MBTL1CHEK2 | |
| SCHEMBL1084882 | 0.75 | ALDH1A1 (0.55) | MAPTTSHRALDH1A1L3MBTL1CHEK2 | |
| SCHEMBL1621664 | 0.75 | MAPT (0.42) | MAPTTSHRALDH1A1L3MBTL1CHEK2 | |
| Hydrochloric Acid SCHEMBL1624356 | 0.74 | MAPT (0.42) | MAPTTSHRALDH1A1L3MBTL1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784393-A1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006028904-A1 | QUINAZOLINES USEFUL AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-03-16 | — | — | WO | disclosed |