SCHEMBL5505225

SCHEMBL5505225

Cc1c(C(=O)O)[nH]c2ccc(S(=O)(=O)N3CC(C)CC(C)C3)cc12

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.61
KDM4E B2RXH2 3/20 0.52
HTT P42858 2/20 0.52
CNR1 P21554 9/20 0.50
CNR2 P34972 8/20 0.50
LMNA P02545 2/20 0.50
MAPT P10636 2/20 0.50
NPSR1 Q6W5P4 2/20 0.50
NR2F2 P24468 1/20 0.50
TP53 P04637 1/20 0.50
TSHR P16473 1/20 0.50
CYP2C9 P11712 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
POLB P06746 1/20 0.47
USP2 O75604 1/20 0.47
ALDH1A1 P00352 1/20 0.47
GAA P10253 1/20 0.47
RXFP1 Q9HBX9 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8275514 0.91 HPGD (0.56) HPGDKDM4EHTTCNR1CNR2
SCHEMBL10259566 0.89 HPGD (0.54) HPGDKDM4EHTTCNR1CNR2
SCHEMBL10259752 0.87 NPSR1 (0.62) HPGDKDM4EHTTCNR1CNR2
SCHEMBL10259864 0.86 NPSR1 (0.64) HPGDKDM4EHTTCNR1CNR2
SCHEMBL10261683 0.86 NPSR1 (0.64) HPGDKDM4EHTTCNR1CNR2
SCHEMBL10261057 0.86 CNR1 (0.53) HPGDKDM4EHTTCNR1CNR2
SCHEMBL10259787 0.86 LMNA (0.54) HPGDKDM4EHTTCNR1CNR2
SCHEMBL10259601 0.86 NR2F2 (0.64) HPGDKDM4EHTTCNR1CNR2
SCHEMBL10261700 0.86 HPGD (0.52) HPGDKDM4EHTTCNR1CNR2
SCHEMBL8276985 0.85 KMT2A (0.54) HPGDKDM4EHTTCNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1776106-B1 HETEROCYCLIC DERIVATIVES FOR MODULATION OF CALCIUM CHANNELS VERTEX PHARMA (US) 2013-08-07 EP disclosed
EP-1776106-A1 HETEROCYCLIC DERIVATIVES FOR MODULATION OF CALCIUM CHANNELS Vertex Pharmaceuticals Incorporated (US) 2007-04-25 EP disclosed
WO-2006010008-A1 HETEROCYCLIC DERIVATIVES FOR MODULATION OF CALCIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2006-01-26 WO disclosed