Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL43478 | 0.94 | — | — | |
| Bicarbonate SCHEMBL3735671 | 0.94 | — | — | |
| Bicarbonate SCHEMBL7906786 | 0.94 | CA4 (0.50) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL10957196 | 0.88 | CA4 (0.60) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL15104746 | 0.88 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL9678485 | 0.88 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL2227181 | 0.88 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL21059472 | 0.88 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL5967928 | 0.88 | CA4 (0.46) | CA4CA1FAHD1CA2CA9 | |
| Bicarbonate SCHEMBL1257653 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791441-A1 | MINERAL FEED SUPPLEMENT | CAN TECHNOLOGIES, INC. (US) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006034098-A1 | MINERAL FEED SUPPLEMENT | CAN TECHNOLOGIES, INC. (US) | 2006-03-30 | — | — | WO | disclosed |