Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LDHA | P00338 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL43478 | 1.00 | — | — | |
| Bicarbonate SCHEMBL1257653 | 0.94 | — | — | |
| Bicarbonate SCHEMBL10389404 | 0.94 | CA4 (0.46) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL8776836 | 0.94 | — | — | |
| Bicarbonate SCHEMBL2227181 | 0.94 | CA4 (0.46) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL5359209 | 0.94 | CA4 (0.46) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL15104746 | 0.94 | CA4 (0.46) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL6018858 | 0.94 | — | — | |
| Bicarbonate SCHEMBL21059472 | 0.94 | CA4 (0.46) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL10957196 | 0.94 | CA4 (0.60) | CA4CA1CA2CA9FAHD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117777153-A | 20 (S) -10, 11-difluoro methylenedioxy camptothecine derivative and preparation method and application thereof | 浙江工业大学 | 2024-03-29 | — | — | CN | claimed |
| US-6193904-B1 | MIXING SEPARATELY PRECIPITATED FERROUS DICARBOXYLATE AND A SECOND METAL DICARBOXYLATE, CALCINING TO FORM THE FERRITE POWDER FOR USE IN A MICROWAVE ELEMENT | NORTHROP GRUMMAN CORPORATION | 2001-02-27 | — | — | US | claimed |
| JP-58132042-A | — | — | None | — | — | JP | disclosed |
| CN-117777153-A | 20 (S) -10, 11-difluoro methylenedioxy camptothecine derivative and preparation method and application thereof | 浙江工业大学 | 2024-03-29 | — | — | CN | disclosed |
| US-20140134290-A1 | ANIMAL FEED ADDITIVES | Inco Digestive, Inc. (US) | 2014-05-15 | — | — | US | disclosed |
| WO-2013012657-A1 | ANIMAL FEED ADDITIVES | INCO DIGESTIVE, LLC (US) | 2013-01-24 | — | — | WO | disclosed |
| US-20130022706-A1 | Animal Feed Additive | INCO DIGESTIVE, LLC (US) | 2013-01-24 | — | — | US | disclosed |
| JP-S58132042-A | BITUMINOUS MATERIAL COMPOSITION | TOBISHIMA KENSETSU KK | 1983-08-06 | — | — | JP | disclosed |