Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.59 |
| ▸ | FAAH | O00519 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 4/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14519882 | 0.97 | CA2 (0.63) | CA2FAAHTP53CES1CES2 | |
| SCHEMBL27050891 | 0.97 | CA2 (0.63) | CA2FAAHTP53CES1CES2 | |
| SCHEMBL11101496 | 0.97 | CA2 (0.63) | CA2FAAHTP53CES1CES2 | |
| SCHEMBL1911477 | 0.97 | CA2 (0.63) | CA2FAAHTP53CES1CES2 | |
| SCHEMBL2305626 | 0.92 | CA2 (0.50) | CA2FAAHTP53CES1NPC1 | |
| SCHEMBL8594180 | 0.81 | CA2 (0.56) | CA2FAAHTP53CES1TRPM8 | |
| SCHEMBL1704503 | 0.80 | — | — | |
| SCHEMBL7675688 | 0.80 | CA2 (0.55) | CA2FAAHTP53CES1CES2 | |
| SCHEMBL16473946 | 0.80 | HTT (0.56) | CA2LMNAHTT | |
| SCHEMBL10707328 | 0.79 | CA2 (0.59) | CA2FAAHCES1CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819692-A1 | 3-ETHYLIDENEHYDRAZINO SUBSTITUTED HETEROCYCLIC COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS | Nissan Chemical Industries, Ltd. (JP) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006062240-A1 | 3-ETHYLIDENEHYDRAZINO SUBSTITUTED HETEROCYCLIC COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 2006-06-15 | — | — | WO | disclosed |