Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 3/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5505668 | 1.00 | CISD1 (0.46) | CISD1MEN1KMT2AGAAXDH | |
| SCHEMBL14452267 | 1.00 | CISD1 (0.46) | CISD1MEN1KMT2AGAAXDH | |
| SCHEMBL5505339 | 0.88 | CISD1 (0.48) | CISD1MEN1KMT2AGAAXDH | |
| SCHEMBL14437310 | 0.88 | CISD1 (0.48) | CISD1MEN1KMT2AGAAXDH | |
| SCHEMBL5505342 | 0.88 | CISD1 (0.48) | CISD1MEN1KMT2AGAAXDH | |
| SCHEMBL3862750 | 0.84 | CISD1 (0.44) | CISD1MEN1KMT2AGAAXDH | |
| SCHEMBL3862753 | 0.84 | CISD1 (0.44) | CISD1MEN1KMT2AGAAXDH | |
| SCHEMBL13897315 | 0.84 | CISD1 (0.44) | CISD1MEN1KMT2AGAAXDH | |
| SCHEMBL3868935 | 0.83 | CISD1 (0.48) | CISD1MEN1KMT2AGAAXDH | |
| SCHEMBL3864350 | 0.83 | CISD1 (0.48) | CISD1MEN1KMT2AGAAXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101018785-A | Thiazolinone 2-substituted quinolines | HOFFMANN LA ROCHE (CH) | 2007-08-15 | — | — | CN | claimed |
| US-7241893-B2 | Thiazolinone 2-substituted quinolines | HOFFMAN-LA ROCHE INC. (US) | 2007-07-10 | — | — | US | claimed |
| EP-1791836-A1 | THIAZOLINONE 2-SUBSTITUTED QUINOLINES | F. Hoffmann-Roche AG (CH) | 2007-06-06 | — | — | EP | claimed |
| US-20060063804-A1 | Thiazolinone 2-substituted quinolines | CHEN LI | 2006-03-23 | — | — | US | claimed |
| WO-2006029863-A1 | THIAZOLINONE 2-SUBSTITUTED QUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-23 | — | — | WO | claimed |
| CN-101018785-A | Thiazolinone 2-substituted quinolines | HOFFMANN LA ROCHE (CH) | 2007-08-15 | — | — | CN | disclosed |
| US-7241893-B2 | Thiazolinone 2-substituted quinolines | HOFFMAN-LA ROCHE INC. (US) | 2007-07-10 | — | — | US | disclosed |
| EP-1791836-A1 | THIAZOLINONE 2-SUBSTITUTED QUINOLINES | F. Hoffmann-Roche AG (CH) | 2007-06-06 | — | — | EP | disclosed |
| US-20060063804-A1 | Thiazolinone 2-substituted quinolines | CHEN LI | 2006-03-23 | — | — | US | disclosed |
| WO-2006029863-A1 | THIAZOLINONE 2-SUBSTITUTED QUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063804-A1 | Thiazolinone 2-substituted quinolines | CDK1, CDK17, CDK12 | CISD1 1028/4885MEN1 1507/4885KMT2A 647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.