Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3862750 | 1.00 | CISD1 (0.44) | CISD1ALOX5MEN1KMT2AXDH | |
| SCHEMBL3862753 | 1.00 | CISD1 (0.44) | CISD1ALOX5MEN1KMT2AXDH | |
| SCHEMBL3864350 | 0.88 | CISD1 (0.48) | CISD1ALOX5MEN1KMT2AXDH | |
| SCHEMBL3868935 | 0.88 | CISD1 (0.48) | CISD1ALOX5MEN1KMT2AXDH | |
| SCHEMBL3864349 | 0.88 | CISD1 (0.48) | CISD1ALOX5MEN1KMT2AXDH | |
| SCHEMBL14452267 | 0.84 | CISD1 (0.46) | CISD1ALOX5MEN1KMT2AXDH | |
| SCHEMBL5505672 | 0.84 | CISD1 (0.46) | CISD1ALOX5MEN1KMT2AXDH | |
| SCHEMBL5505668 | 0.84 | CISD1 (0.46) | CISD1ALOX5MEN1KMT2AXDH | |
| SCHEMBL5505339 | 0.83 | CISD1 (0.48) | CISD1ALOX5MEN1KMT2AXDH | |
| SCHEMBL14437310 | 0.83 | CISD1 (0.48) | CISD1ALOX5MEN1KMT2AXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7501428-B2 | e.g. 2-(1-hydroxymethyl-2-phenyl-ethylamino)-5-[1-quinazolin-6-yl-methylidene]-thiazol-4-one; cyclin-dependent kinases (CDKs)/serine-threonine protein kinases inhibitor; antiproliferative, anticarcinogenic, antitumor agent | HOFFMANN-LA ROCHE INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-7501428-B2 | e.g. 2-(1-hydroxymethyl-2-phenyl-ethylamino)-5-[1-quinazolin-6-yl-methylidene]-thiazol-4-one; cyclin-dependent kinases (CDKs)/serine-threonine protein kinases inhibitor; antiproliferative, anticarcinogenic, antitumor agent | HOFFMANN-LA ROCHE INC. (US) | 2009-03-10 | — | — | US | disclosed |