Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 17/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 16/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 13/20 | 0.34 |
| ▸ | USP2 | O75604 | 10/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 10/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.34 |
| ▸ | TSHR | P16473 | 7/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.34 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14437293 | 0.87 | MEN1 (0.40) | CYP1A2CYP3A4CLK4USP2CYP2D6 | |
| SCHEMBL5507005 | 0.84 | CLK1 (0.34) | CLK4LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL5502564 | 0.83 | CLK4 (0.38) | CYP1A2CYP3A4CLK4USP2CYP2D6 | |
| SCHEMBL5505196 | 0.82 | SLC2A1 (0.36) | TSHRLMNAMAPK1ALDH1A1MEN1 | |
| SCHEMBL5508501 | 0.82 | ABL1 (0.33) | CYP3A4PDPK1PDE10A | |
| SCHEMBL5508740 | 0.80 | CISD1 (0.36) | CYP3A4LMNAMEN1KMT2APDPK1 | |
| SCHEMBL5502774 | 0.80 | HTT (0.35) | CLK4MEN1KMT2APDPK1KDM4E | |
| SCHEMBL5510707 | 0.76 | KDM1A (0.37) | PDPK1 | |
| SCHEMBL5503592 | 0.76 | CLK4 (0.42) | CYP1A2CYP3A4CLK4USP2CYP2D6 | |
| SCHEMBL3025813 | 0.75 | EGFR (0.37) | MAPK1PDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253285-B2 | Thiazolinone 4-monosubstituted quinolines | HOFFMANN-LA ROCHE INC. (US) | 2007-08-07 | — | — | US | disclosed |
| EP-1797085-A1 | THIAZOLINONE 4-MONOSUBSTITUTED QUINOLINES | F. Hoffmann-Roche AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| US-20060063805-A1 | Thiazolinone 4-monosubstituted quinolines | CHEN LI | 2006-03-23 | — | — | US | disclosed |
| WO-2006029861-A1 | THIAZOLINONE 4-MONOSUBSTITUTED QUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060063805-A1 | Thiazolinone 4-monosubstituted quinolines | CDK1, CDK14, CDK17 | CYP1A2 3343/4885CYP3A4 2153/4885CLK4 327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.