Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL408875 | 1.00 | SMN1; SMN2 (0.44) | SMN1; SMN2HSD17B10BTKNR1H2NR1H3 | |
| SCHEMBL3240371 | 0.91 | SMN1; SMN2 (0.41) | SMN1; SMN2HSD17B10NR1H2NR1H3PTPN1 | |
| SCHEMBL2680322 | 0.90 | SMN1; SMN2 (0.40) | SMN1; SMN2HSD17B10NR1H2NR1H3PTPN1 | |
| SCHEMBL7874236 | 0.90 | SMN1; SMN2 (0.40) | SMN1; SMN2HSD17B10NR1H2NR1H3PTPN1 | |
| SCHEMBL8120922 | 0.88 | HSD17B10 (0.51) | SMN1; SMN2HSD17B10BTKNR1H2POLB | |
| SCHEMBL5521638 | 0.87 | SMN1; SMN2 (0.39) | SMN1; SMN2HSD17B10NR1H2NR1H3PTPN1 | |
| SCHEMBL5521636 | 0.87 | SMN1; SMN2 (0.39) | SMN1; SMN2HSD17B10NR1H2NR1H3PTPN1 | |
| SCHEMBL5521633 | 0.87 | SMN1; SMN2 (0.39) | SMN1; SMN2HSD17B10NR1H2NR1H3PTPN1 | |
| SCHEMBL10592282 | 0.87 | HSD17B10 (0.42) | SMN1; SMN2HSD17B10BTKNR1H2NR1H3 | |
| SCHEMBL20212525 | 0.87 | HSD17B10 (0.42) | SMN1; SMN2HSD17B10BTKNR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799676-A2 | NEW BICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006032466-A2 | NEW BICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-30 | — | — | WO | disclosed |