Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNPAT | O15228 | 1/20 | 0.61 |
| ▸ | ALB | P02768 | 2/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP3 | P08254 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | GGT1 | P19440 | 1/20 | 0.50 |
| ▸ | CPA1 | P15085 | 2/20 | 0.48 |
| ▸ | CPA2 | P48052 | 2/20 | 0.48 |
| ▸ | CPA4 | Q9UI42 | 2/20 | 0.48 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14400980 | 1.00 | GNPAT (0.61) | GNPATALBMMP1MMP3FOLH1 | |
| SCHEMBL16329068 | 0.90 | GNPAT (0.51) | GNPATALBMMP1MMP3CPA1 | |
| SCHEMBL468905 | 0.90 | GNPAT (0.57) | GNPATALBCPA1CPA2CPA4 | |
| SCHEMBL468907 | 0.90 | GNPAT (0.57) | GNPATALBCPA1CPA2CPA4 | |
| SCHEMBL6931278 | 0.90 | GNPAT (0.57) | GNPATALBCPA1CPA2CPA4 | |
| SCHEMBL24814078 | 0.88 | ALB (0.56) | GNPATALBMMP1MMP3CPA1 | |
| SCHEMBL8226798 | 0.86 | CA12 (0.51) | GNPATCA12CA1CA2CA3 | |
| SCHEMBL24814572 | 0.86 | MMP1 (0.58) | GNPATMMP1MMP3CPA1CPA2 | |
| SCHEMBL720665 | 0.86 | CA12 (0.51) | GNPATCA12CA1CA2CA3 | |
| SCHEMBL715466 | 0.86 | CA12 (0.51) | GNPATCA12CA1CA2CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003087036-A1 | STEREOSELECTIVE PROCESS FOR THE SYNTHESIS OF (D)-2-AMINO-5-PHENYLPENTANOIC OR ALKYL ESTER THEREOF | ELI LILLY AND COMPANY (US) | 2003-10-23 | — | — | WO | claimed |
| EP-3277671-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER | Bristol-Myers Squibb Company (US) | 2018-02-07 | — | — | EP | disclosed |
| EP-3277672-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER | Bristol-Myers Squibb Company (US) | 2018-02-07 | — | — | EP | disclosed |
| EP-3277670-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER | Bristol-Myers Squibb Company (US) | 2018-02-07 | — | — | EP | disclosed |
| WO-2016161269-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-10-06 | — | — | WO | disclosed |
| WO-2016161279-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-10-06 | — | — | WO | disclosed |
| WO-2016161286-A1 | INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2016-10-06 | — | — | WO | disclosed |
| EP-1153034-B1 | GROWTH HORMONE SECRETAGOGUES | LILLY CO ELI (US) | 2007-10-17 | — | — | EP | disclosed |
| EP-1153034-B1 | GROWTH HORMONE SECRETAGOGUES | LILLY CO ELI (US) | 2007-10-17 | — | — | EP | disclosed |
| US-6992097-B2 | Growth hormone secretagogues | ELI LILLY AND COMPANY (US) | 2006-01-31 | — | — | US | disclosed |
| WO-1997034604-A1 | 4-SPIROINDOLINE PIPERIDINES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1997-09-25 | — | — | WO | disclosed |
| WO-1997019068-A1 | SULFONAMIDE INHIBITORS OF MATRIX METALLOPROTEINASES | WARNER-LAMBERT COMPANY (US) | 1997-05-29 | — | — | WO | disclosed |
| US-5622973-A | BONE DISORDERS | MERCK & CO., INC. (US) | 1997-04-22 | — | — | US | disclosed |
| WO-1997011697-A1 | 3-SPIROLACTAM, 3-SPIROAMINO, 3-SPIROLACTONE AND 3-SPIROBENZOPYRAN PIPERIDINES AND PYRROLIDINES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1997-04-03 | — | — | WO | disclosed |
| WO-1996032943-A1 | 3-SUBSTITUTED PIPERIDINES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1996-10-24 | — | — | WO | disclosed |
| US-5559128-A | FOOD ANIMALS; MEDICAL DIAGNOSIS | MERCK & CO., INC. (US) | 1996-09-24 | — | — | US | disclosed |
| US-5494919-A | TREATING GROWTH HORMONE DEFICIENCY, INCREASING MEAT PRODUCTION | MERCK & CO., INC. (US) | 1996-02-27 | — | — | US | disclosed |
| US-5492916-A | Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone | MERCK & CO., INC. (US) | 1996-02-20 | — | — | US | disclosed |
| WO-1996002530-A1 | PIPERIDINES AND HEXAHYDRO-1H-AZEPINES SPIRO SUBSTITUTED AT THE 4-POSITION PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1996-02-01 | — | — | WO | disclosed |
| WO-1995013069-A1 | PIPERIDINES, PYRROLIDINES AND HEXAHYDRO-1H-AZEPINES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1995-05-18 | — | — | WO | disclosed |