Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 16/20 | 0.53 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506279 | 1.00 | MAPKAPK2 (0.53) | MAPKAPK2SLC2A1MTORADRA2AADRA2B | |
| SCHEMBL4155440 | 0.89 | MAPKAPK2 (0.57) | MAPKAPK2SLC2A1ADRA2AADRA2BADRA2C | |
| SCHEMBL4153291 | 0.89 | MAPKAPK2 (0.57) | MAPKAPK2SLC2A1ADRA2AADRA2BADRA2C | |
| SCHEMBL4153297 | 0.89 | MAPKAPK2 (0.57) | MAPKAPK2SLC2A1ADRA2AADRA2BADRA2C | |
| SCHEMBL4141263 | 0.87 | MAPKAPK2 (0.54) | MAPKAPK2SLC2A1 | |
| SCHEMBL5516875 | 0.86 | MAPKAPK2 (0.51) | MAPKAPK2 | |
| SCHEMBL4153294 | 0.79 | MAPKAPK2 (0.83) | MAPKAPK2SLC2A1ADRA2AADRA2BADRA2C | |
| SCHEMBL4143228 | 0.77 | MAPKAPK2 (0.68) | MAPKAPK2 | |
| SCHEMBL4146762 | 0.77 | MAPKAPK2 (0.56) | MAPKAPK2 | |
| SCHEMBL4151379 | 0.77 | MAPKAPK2 (0.69) | MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781293-A1 | QUINOLINE- AND ISOQUINOLINE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | Amphora Discovery Corporation (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2005120509-A1 | QUINOLINE- AND ISOQUINOLINE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |