Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 17/20 | 0.51 |
| ▸ | MELK | Q14680 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4146627 | 0.90 | MAPKAPK2 (0.56) | MAPKAPK2MELK | |
| SCHEMBL5506286 | 0.86 | MAPKAPK2 (0.53) | MAPKAPK2 | |
| SCHEMBL5506279 | 0.86 | MAPKAPK2 (0.53) | MAPKAPK2 | |
| SCHEMBL4140347 | 0.84 | MAPKAPK2 (0.55) | MAPKAPK2MELK | |
| SCHEMBL4154685 | 0.83 | MAPKAPK2 (0.56) | MAPKAPK2 | |
| SCHEMBL4154112 | 0.81 | MAPKAPK2 (0.56) | MAPKAPK2MELK | |
| SCHEMBL4145451 | 0.81 | MAPKAPK2 (0.55) | MAPKAPK2MELK | |
| SCHEMBL4143228 | 0.80 | MAPKAPK2 (0.68) | MAPKAPK2 | |
| SCHEMBL4141129 | 0.79 | MAPKAPK2 (0.54) | MAPKAPK2MELKRAF1BRAF | |
| SCHEMBL4161518 | 0.79 | MAPKAPK2 (0.55) | MAPKAPK2MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781293-A1 | QUINOLINE- AND ISOQUINOLINE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | Amphora Discovery Corporation (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2005120509-A1 | QUINOLINE- AND ISOQUINOLINE-BASED COMPOUNDS EXHIBITING ATP-UTILIZING ENZYME INHIBITORY ACTIVITY, AND COMPOSITIONS, AND USES THEREOF | AMPHORA DISCOVERY CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |