SCHEMBL5506465

SCHEMBL5506465

c1cncc(C2NCC23CC3)c1

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 8/20 0.51
CHRNA4 P43681 8/20 0.51
CHRNA7 P36544 5/20 0.50
CYP2A6 P11509 3/20 0.50
MEN1 O00255 2/20 0.50
CYP2D6 P10635 2/20 0.50
CYP2C19 P33261 2/20 0.50
KMT2A Q03164 2/20 0.50
POLB P06746 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
CYP1A2 P05177 1/20 0.50
CYP2C9 P11712 1/20 0.50
CYP11B2 P19099 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30503595 0.87 CHRNB2 (0.49) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
SCHEMBL157893 0.79 CHRNB2 (0.51) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
SCHEMBL5507522 0.78
SCHEMBL27467551 0.71
SCHEMBL5507734 0.71 CHRNB2 (0.34) CHRNB2CHRNA4POLB
SCHEMBL5507253 0.71 CHRNB2 (0.45) CHRNB2CHRNA4CHRNA7MEN1KMT2A
SCHEMBL5507467 0.70 CHRNB2 (0.38) CHRNB2CHRNA4CHRNA7
SCHEMBL3463921 0.69 CHRNB2 (0.47) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
SCHEMBL159642 0.68 CHRNB2 (1.00) CHRNB2CHRNA4CHRNA7CYP2A6MEN1
SCHEMBL5031473 0.68 CHRNB2 (0.46) CHRNB2CHRNA4CHRNA7CYP2A6MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1802601-A1 AZASPIROALKENE AND AZAPIROALKANE COMPOUNDS WITH NICOTINIC CHOLINERGIC RECEPTOR ACTIVITY Targacept, Inc. (US) 2007-07-04 EP claimed
WO-2006034089-A1 AZASPIROALKENE AND AZASPIROALKANE COMPOUNDS WITH NICOTINIC CHOLINERGIC RECEPTOR ACTIVITY TARGACEPT, INC. (US) 2006-03-30 WO claimed
EP-1802601-A1 AZASPIROALKENE AND AZAPIROALKANE COMPOUNDS WITH NICOTINIC CHOLINERGIC RECEPTOR ACTIVITY Targacept, Inc. (US) 2007-07-04 EP disclosed
WO-2006034089-A1 AZASPIROALKENE AND AZASPIROALKANE COMPOUNDS WITH NICOTINIC CHOLINERGIC RECEPTOR ACTIVITY TARGACEPT, INC. (US) 2006-03-30 WO disclosed