SCHEMBL5506580

SCHEMBL5506580

Cc1ccc(Oc2ccc(Nc3ncnc4ccc(-c5nc(N)sc5S(C)(=O)=O)cc34)cc2C)cn1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
EGFR P00533 12/20 0.54
HDAC1 Q13547 2/20 0.54
HDAC6 Q9UBN7 2/20 0.54
ERBB2 P04626 15/20 0.51
ERBB3 P21860 1/20 0.51
ERBB4 Q15303 1/20 0.51
FECH P22830 1/20 0.49
CDK8 P49336 1/20 0.49
MAP2K5 Q13163 1/20 0.49
CDK19 Q9BWU1 1/20 0.49
MKNK2 Q9HBH9 1/20 0.49
KCNH2 Q12809 3/20 0.46
GCK P35557 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4866251 0.80 EGFR (0.67) EGFRHDAC1HDAC6ERBB2ERBB3
SCHEMBL4468668 0.79 EGFR (0.67) EGFRHDAC1HDAC6ERBB2ERBB3
SCHEMBL216565 0.79 EGFR (0.55) EGFRHDAC1HDAC6ERBB2ERBB3
SCHEMBL24832693 0.77 ERBB2 (0.68) EGFRHDAC1HDAC6ERBB2ERBB3
SCHEMBL24569330 0.76 ERBB2 (0.67) EGFRHDAC1HDAC6ERBB2ERBB3
SCHEMBL29888726 0.76 ERBB2 (0.67) EGFRHDAC1HDAC6ERBB2ERBB3
SCHEMBL5564348 0.76 ERBB2 (0.66) EGFRHDAC1HDAC6ERBB2ERBB3
SCHEMBL2702250 0.76 ERBB2 (0.66) EGFRHDAC1HDAC6ERBB2ERBB3
SCHEMBL5251879 0.76 ERBB2 (0.66) EGFRHDAC1HDAC6ERBB2ERBB3
SCHEMBL6846207 0.75 EGFR (0.59) EGFRHDAC1HDAC6ERBB2ERBB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1567506-A4 CYANOGUANIDINES AND CYANOAMIDINES AS ERBB2 AND EGFR INHIBITORS ARRAY BIOPHARMA INC (US) 2007-06-20 EP disclosed
EP-1567506-A2 CYANOGUANIDINES AND CYANOAMIDINES AS ERBB2 AND EGFR INHIBITORS Array Biopharma, Inc. (US) 2005-08-31 EP disclosed
WO-2004046101-A2 CYANOGUANIDINES AND CYANOAMIDINES AS ERBB2 AND EGFR INHIBITORS ARRAY BIOPHARMA, INC. (US) 2004-06-03 WO disclosed