Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.59 |
| ▸ | ERBB2 | P04626 | 12/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | FECH | P22830 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.48 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.47 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4468668 | 0.94 | EGFR (0.67) | EGFRERBB2MEN1MAPK1KMT2A | |
| SCHEMBL216565 | 0.84 | EGFR (0.55) | EGFRERBB2MEN1MAPK1KMT2A | |
| SCHEMBL2736365 | 0.80 | EGFR (0.50) | EGFRERBB2MEN1MAPK1KMT2A | |
| SCHEMBL216405 | 0.80 | EGFR (0.50) | EGFRERBB2MEN1MAPK1KMT2A | |
| SCHEMBL4475255 | 0.79 | EGFR (0.65) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL216406 | 0.77 | EGFR (0.50) | EGFRERBB2HDAC1HDAC6FECH | |
| SCHEMBL2099768 | 0.77 | EGFR (0.84) | EGFRERBB2MEN1MAPK1KMT2A | |
| SCHEMBL4011172 | 0.77 | EGFR (0.89) | EGFRERBB2MEN1MAPK1KMT2A | |
| SCHEMBL4010606 | 0.77 | EGFR (0.76) | EGFRERBB2MEN1MAPK1KMT2A | |
| SCHEMBL5506580 | 0.75 | EGFR (0.54) | EGFRERBB2HDAC1HDAC6FECH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040242604-A1 | Substituted heterocycles for the treatment of abnormal cell growth | PFIZER INC | 2004-12-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242604-A1 | Substituted heterocycles for the treatment of abnormal cell growth | CCNA1, CCNT1, CCNY | EGFR 166/4885ERBB2 1183/4885MEN1 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.