Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.41 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4201836 | 0.93 | KMT2A (0.53) | MEN1KMT2AGAAMAPTBMPR1B | |
| SCHEMBL30661549 | 0.93 | KMT2A (0.53) | MEN1KMT2AGAAMAPTBMPR1B | |
| SCHEMBL5503760 | 0.87 | KMT2A (0.46) | MEN1KMT2AGAAMAPTHTT | |
| SCHEMBL4200813 | 0.82 | NOTUM (0.51) | KMT2AGAABMPR1BBMPR1ATGFBR1 | |
| SCHEMBL8127050 | 0.81 | SIRT2 (0.49) | MEN1KMT2AGAAMAPTLMNA | |
| SCHEMBL5108618 | 0.81 | GAA (0.49) | MEN1KMT2AGAAMAPTHTT | |
| SCHEMBL5115938 | 0.80 | GAA (0.48) | MEN1KMT2AGAAMAPTLMNA | |
| SCHEMBL5506721 | 0.80 | GAA (0.51) | MEN1KMT2AGAAMAPTBMPR1B | |
| SCHEMBL2061340 | 0.79 | CASP6 (0.52) | MEN1KMT2AGAAMAPTHTT | |
| SCHEMBL23055602 | 0.78 | MEN1 (0.46) | MEN1KMT2AGAAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869029-A1 | AN OXINDOLE OXAZOLIDINONE AS ANTIBACTERIAL AGENT | Pharmacia & Upjohn Company LLC (US) | 2007-12-26 | — | — | EP | disclosed |
| EP-1781643-A1 | OXINDOLE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS | Pharmacia & Upjohn Company LLC (US) | 2007-05-09 | — | — | EP | disclosed |
| EP-1781642-A1 | OXAZOLIDINONES CONTAINING OXINDOLES AS ANTIBACTERIAL AGENTS | Pharmacia & Upjohn Company LLC (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006106426-A1 | AN OXINDOLE OXAZOLIDINONE AS ANTIBACTERIAL AGENT | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-10-12 | — | — | WO | disclosed |
| WO-2006016221-A1 | OXAZOLIDINONES CONTAINING OXINDOLES AS ANTIBACTERIAL AGENTS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-02-16 | — | — | WO | disclosed |
| WO-2006016220-A1 | OXINDOLE OXAZOLIDINONES AS ANTIBACTERIAL AGENTS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-02-16 | — | — | WO | disclosed |