Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503762 | 0.91 | PDE4D (0.48) | PDE4DPDE4BPDE4APDE4CMCHR1 | |
| SCHEMBL5506282 | 0.91 | PDE4D (0.48) | PDE4DPDE4BPDE4APDE4CMCHR1 | |
| SCHEMBL5510203 | 0.91 | PDE4D (0.48) | PDE4DPDE4BPDE4APDE4CMCHR1 | |
| SCHEMBL5509736 | 0.87 | PDE4D (0.42) | PDE4DPDE4BPDE4APDE4CMCHR1 | |
| SCHEMBL5063164 | 0.83 | PDE4D (0.43) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL2264024 | 0.82 | PDE4D (0.40) | PDE4DPDE4BPDE4APDE4CCYP1A2 | |
| SCHEMBL5483281 | 0.82 | PDE4D (0.43) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL2266059 | 0.81 | PDE4D (0.45) | PDE4DPDE4BPDE4APDE4CCYP1A2 | |
| SCHEMBL18092833 | 0.81 | PDE4D (0.45) | PDE4DPDE4BPDE4APDE4CCYP1A2 | |
| SCHEMBL1411087 | 0.81 | PDE4D (0.45) | PDE4DPDE4BPDE4APDE4CCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070191413-A1 | Novel heterocycle-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors | ATLANTA PHARMA AG (DE) | 2007-08-16 | — | — | US | claimed |
| EP-1812400-A1 | NOVEL HETEROCYCLYL-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | Altana Pharma AG (DE) | 2007-08-01 | — | — | EP | claimed |
| WO-2005090311-A1 | NOVEL HETEROCYCLYL-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-09-29 | — | — | WO | claimed |
| US-20070191413-A1 | Novel heterocycle-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors | ATLANTA PHARMA AG (DE) | 2007-08-16 | — | — | US | disclosed |
| EP-1812400-A1 | NOVEL HETEROCYCLYL-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | Altana Pharma AG (DE) | 2007-08-01 | — | — | EP | disclosed |
| WO-2005090311-A1 | NOVEL HETEROCYCLYL-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | ALTANA PHARMA AG (DE) | 2005-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191413-A1 | Novel heterocycle-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors | PDE4A, PDE4B, PDE4C | PDE4D 4/4885PDE4B 2/4885PDE4A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.