Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | MC5R | P33032 | 1/20 | 0.35 |
| ▸ | MC3R | P41968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5511290 | 0.86 | BRD4 (0.48) | ALDH1A1L3MBTL1BRD4KDM4EHSD17B10 | |
| SCHEMBL5521234 | 0.78 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1BRD4KDM4EHSD17B10 | |
| SCHEMBL2874923 | 0.78 | BRD4 (0.49) | ALDH1A1L3MBTL1BRD4KDM4EHSD17B10 | |
| SCHEMBL5514824 | 0.78 | BRD4 (0.49) | ALDH1A1L3MBTL1BRD4KDM4EHSD17B10 | |
| SCHEMBL2869220 | 0.77 | BRD4 (0.47) | ALDH1A1L3MBTL1BRD4KDM4EHSD17B10 | |
| SCHEMBL13774339 | 0.77 | BRD4 (0.48) | ALDH1A1L3MBTL1BRD4KDM4EHSD17B10 | |
| SCHEMBL5512629 | 0.77 | BRD4 (0.50) | ALDH1A1L3MBTL1BRD4KDM4EHSD17B10 | |
| SCHEMBL2877960 | 0.76 | BRD4 (0.47) | ALDH1A1L3MBTL1BRD4KDM4EHSD17B10 | |
| SCHEMBL2875763 | 0.74 | BRD4 (0.46) | ALDH1A1L3MBTL1BRD4KDM4EHSD17B10 | |
| SCHEMBL5621493 | 0.73 | BRD4 (0.45) | ALDH1A1L3MBTL1BRD4KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844011-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | Aventis Pharmaceuticals Inc. (US) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006081343-A1 | 2-PHENYL-INDOLES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | AVENTIS PHARMACEUTICALS INC. (US) | 2006-08-03 | — | — | WO | disclosed |