Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | IDO1 | P14902 | 10/20 | 0.44 |
| ▸ | AR | P10275 | 5/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17729172 | 0.86 | IDO1 (0.59) | PIK3CDPIK3CAPIK3CBPIK3CGIDO1 | |
| SCHEMBL5499611 | 0.85 | IDO1 (0.55) | PIK3CDPIK3CAPIK3CBPIK3CGIDO1 | |
| SCHEMBL23360348 | 0.78 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGIDO1 | |
| SCHEMBL23360352 | 0.78 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGIDO1 | |
| SCHEMBL23360649 | 0.75 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL23360651 | 0.75 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL17729245 | 0.74 | HRH1 (0.42) | — | |
| SCHEMBL5506914 | 0.74 | PIK3CD (0.39) | PIK3CDPIK3CAPIK3CBPIK3CGIDO1 | |
| SCHEMBL29862644 | 0.73 | IDO1 (0.56) | PIK3CDPIK3CAPIK3CBPIK3CGIDO1 | |
| SCHEMBL23360277 | 0.73 | IDO1 (0.56) | PIK3CDPIK3CAPIK3CBPIK3CGIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797085-A1 | THIAZOLINONE 4-MONOSUBSTITUTED QUINOLINES | F. Hoffmann-Roche AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006029861-A1 | THIAZOLINONE 4-MONOSUBSTITUTED QUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-23 | — | — | WO | disclosed |