Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 7/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.33 |
| ▸ | AR | P10275 | 4/20 | 0.32 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | MST1R | Q04912 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504950 | 0.89 | IDO1 (0.46) | PIK3CDPIK3CAPIK3CBPIK3CGIDO1 | |
| SCHEMBL3945087 | 0.82 | CHRM4 (0.36) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5507128 | 0.74 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGIDO1 | |
| SCHEMBL17729172 | 0.74 | IDO1 (0.59) | PIK3CDPIK3CAPIK3CBPIK3CGIDO1 | |
| SCHEMBL5503407 | 0.70 | KMT2A (0.44) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3950194 | 0.70 | ERBB2 (0.35) | IRAK4 | |
| SCHEMBL5507155 | 0.68 | IDO1 (0.54) | PIK3CDPIK3CAPIK3CBPIK3CGIDO1 | |
| SCHEMBL14437316 | 0.67 | GPR119 (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGIDO1 | |
| SCHEMBL23360352 | 0.67 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGIDO1 | |
| SCHEMBL23360348 | 0.67 | PIK3CD (0.58) | PIK3CDPIK3CAPIK3CBPIK3CGIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797085-A1 | THIAZOLINONE 4-MONOSUBSTITUTED QUINOLINES | F. Hoffmann-Roche AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006029861-A1 | THIAZOLINONE 4-MONOSUBSTITUTED QUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-23 | — | — | WO | disclosed |