Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SPOP | O43791 | 10/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5507189 | 1.00 | TDP1 (0.42) | TDP1HSD17B10KDM4ETSHRDRD2 | |
| Trifluoroacetic Acid SCHEMBL8899151 | 0.88 | HDAC1 (0.38) | TDP1HSD17B10KDM4ETSHRMAPT | |
| Trifluoroacetic Acid SCHEMBL8899144 | 0.88 | HDAC1 (0.38) | TDP1HSD17B10KDM4ETSHRMAPT | |
| Trifluoroacetic Acid SCHEMBL8900920 | 0.88 | HDAC1 (0.39) | TDP1HSD17B10KDM4ETSHRMAPT | |
| Trifluoroacetic Acid SCHEMBL8900927 | 0.88 | HDAC1 (0.39) | TDP1HSD17B10KDM4ETSHRMAPT | |
| Trifluoroacetic Acid SCHEMBL8900667 | 0.88 | TDP1 (0.41) | TDP1HSD17B10KDM4ETSHRMAPT | |
| Trifluoroacetic Acid SCHEMBL8900675 | 0.88 | TDP1 (0.41) | TDP1HSD17B10KDM4ETSHRMAPT | |
| Trifluoroacetic Acid SCHEMBL8899336 | 0.87 | TDP1 (0.36) | TDP1HSD17B10KDM4ETSHRMAPT | |
| Trifluoroacetic Acid SCHEMBL8899326 | 0.87 | TDP1 (0.36) | TDP1HSD17B10KDM4ETSHRMAPT | |
| SCHEMBL6373794 | 0.86 | TDP1 (0.44) | TDP1HSD17B10KDM4ETSHRDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841339-B1 | Vinylpyrrolidinon cephalosporin derivatives | BASILEA PHARMACEUTICA AG (CH) | 2007-02-21 | — | — | EP | disclosed |
| US-6294668-B1 | ANTIBACTERIAL ACTIVITY AGAINST BETA-LACTAM SENSITIVE AND RESISTANT GRAM-POSITIVE BACTERIA, SUCH AS STAPHYLOCOCCI, PNEUMOCOCCI, AND ENTEROCOCCI; USED IN THERAPY OF INFECTIOUS DISEASES CAUSED BY THOSE BACTERIA | HOFFMAN-LA ROCHE INC. | 2001-09-25 | — | — | US | disclosed |
| EP-0841339-A1 | Vinylpyrrolidinon cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-05-13 | — | — | EP | disclosed |