Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 3/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
| ▸ | CETP | P11597 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.33 |
| ▸ | VDR | P11473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5501676 | 0.97 | NR1H2 (0.38) | NR1H2NR1H3CETPPTPN1PTPN2 | |
| SCHEMBL5505306 | 0.95 | PTPN1 (0.39) | NR1H2NR1H3PTPN1PTPN2KMO | |
| SCHEMBL5505414 | 0.90 | PTPN5 (0.40) | NR1H2NR1H3CETPPTPN1PTPN2 | |
| SCHEMBL5508244 | 0.87 | PTPN5 (0.42) | NR1H2NR1H3CETPPTPN1PTPN2 | |
| SCHEMBL5507373 | 0.86 | KMO (0.35) | NR1H2NR1H3CETPKMOHPGD | |
| SCHEMBL4957662 | 0.85 | NR1H2 (0.37) | NR1H2NR1H3CETPPTPN1PTPN2 | |
| SCHEMBL5508633 | 0.85 | PTPN5 (0.43) | PTPN1PTPN2KMOTHRB | |
| SCHEMBL5505410 | 0.83 | KMO (0.39) | NR1H2NR1H3CETPKMOHPGD | |
| SCHEMBL5501679 | 0.83 | NR1H2 (0.36) | NR1H2NR1H3CETPHPGDSMN1; SMN2 | |
| SCHEMBL4959788 | 0.83 | PTPN1 (0.38) | PTPN1PTPN2KMOHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786421-A2 | OXYGEN/NITROGEN HETEROCYCLE INHIBITORS OF TYROSINE PHOSPHATASES | Cengent Therapeutics, Inc. (US) | 2007-05-23 | — | — | EP | claimed |
| WO-2006017124-A2 | OXYGEN/NITROGEN HETEROCYCLE INHIBITORS OF TYROSINE PHOSPHATASES | CENGENT THERAPEUTICS, INC. (US) | 2006-02-16 | — | — | WO | claimed |