Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.31 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3537170 | 0.83 | TAS1R3 (0.37) | POLBMAPTTDP1CYP11B1CYP11B2 | |
| SCHEMBL3537172 | 0.83 | TAS1R3 (0.37) | POLBMAPTTDP1CYP11B1CYP11B2 | |
| SCHEMBL3534961 | 0.76 | POLB (0.40) | POLBMAPTTDP1HTTKDM4E | |
| SCHEMBL3534959 | 0.76 | POLB (0.40) | POLBMAPTTDP1HTTKDM4E | |
| SCHEMBL5200548 | 0.72 | HSD17B2 (0.38) | CYP11B1CYP11B2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5200541 | 0.72 | HSD17B2 (0.38) | CYP11B1CYP11B2TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5950467 | 0.70 | HSD17B2 (0.38) | POLBCYP11B1CYP11B2TAS1R3TAS1R1 | |
| SCHEMBL3534846 | 0.70 | BDKRB1 (0.44) | TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL5950470 | 0.70 | HSD17B2 (0.38) | POLBCYP11B1CYP11B2TAS1R3TAS1R1 | |
| SCHEMBL3534842 | 0.70 | BDKRB1 (0.44) | TAS1R3TAS1R1TAS1R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817294-A1 | 1,2,3,4-TETRAHYDROPYRAZIN-2-YL ACETAMIDES AND THEIR USE AS BRADYKININ ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION RELATED DISORDERS | Amgen Inc. (US) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006019975-A1 | 1,2,3,4-TETRAHYDROPYRAZIN-2-YL ACETAMIDES AND THEIR USE AS BRADYKININ ANTAGONISTS FOR THE TREATMENT OF INFLAMMATION RELATED DISORDERS | AMGEN INC. (US) | 2006-02-23 | — | — | WO | disclosed |