Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | SPOP | O43791 | 6/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imidazole SCHEMBL5507660 | 1.00 | CA5A (0.48) | CA5ANR1I2MAPTTDP1POLB | |
| Imidazole SCHEMBL5507020 | 0.94 | CA5A (0.56) | CA5ANR1I2MAPTTDP1POLB | |
| Imidazole SCHEMBL5507022 | 0.94 | CA5A (0.56) | CA5ANR1I2MAPTTDP1POLB | |
| Imidazole SCHEMBL5506560 | 0.94 | CA5A (0.48) | CA5ANR1I2MAPTTDP1POLB | |
| Imidazole SCHEMBL5506557 | 0.94 | CA5A (0.48) | CA5ANR1I2MAPTTDP1POLB | |
| Imidazole SCHEMBL6376218 | 0.91 | CA5A (0.45) | CA5ANR1I2MAPTTDP1POLB | |
| Imidazole SCHEMBL6376214 | 0.91 | CA5A (0.45) | CA5ANR1I2MAPTTDP1POLB | |
| Imidazole SCHEMBL5506257 | 0.90 | CA5A (0.45) | CA5ANR1I2MAPTTDP1POLB | |
| Imidazole SCHEMBL5506254 | 0.90 | CA5A (0.45) | CA5ANR1I2MAPTTDP1POLB | |
| Imidazole SCHEMBL5501784 | 0.87 | CA5A (0.46) | CA5ANR1I2MAPTTDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841339-B1 | Vinylpyrrolidinon cephalosporin derivatives | BASILEA PHARMACEUTICA AG (CH) | 2007-02-21 | — | — | EP | disclosed |
| US-6294668-B1 | ANTIBACTERIAL ACTIVITY AGAINST BETA-LACTAM SENSITIVE AND RESISTANT GRAM-POSITIVE BACTERIA, SUCH AS STAPHYLOCOCCI, PNEUMOCOCCI, AND ENTEROCOCCI; USED IN THERAPY OF INFECTIOUS DISEASES CAUSED BY THOSE BACTERIA | HOFFMAN-LA ROCHE INC. | 2001-09-25 | — | — | US | disclosed |
| EP-0841339-A1 | Vinylpyrrolidinon cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-05-13 | — | — | EP | disclosed |