Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.38 |
| ▸ | KMO | O15229 | 4/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5501605 | 0.83 | MAPT (0.40) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL73469 | 0.79 | PDE4A (0.41) | PDE4APDE4DPDE4BPDE4CMAOB | |
| SCHEMBL73109 | 0.78 | MAOB (0.40) | PDE4APDE4DPDE4BPDE4CKMO | |
| SCHEMBL75163 | 0.76 | PDE4A (0.38) | PDE4APDE4DPDE4BPDE4CMAOB | |
| SCHEMBL73106 | 0.75 | PDE4A (0.37) | PDE4APDE4DPDE4BPDE4CSYK | |
| SCHEMBL72943 | 0.72 | PDE4A (0.43) | PDE4APDE4DPDE4BPDE4CMAOB | |
| SCHEMBL73108 | 0.72 | PDE5A (0.39) | PDE4APDE4DPDE4BPDE4CKMO | |
| SCHEMBL5022607 | 0.71 | CYP19A1 (0.48) | PDE4APDE4DPDE4BPDE4CMAOB | |
| SCHEMBL5505683 | 0.71 | PDE4A (0.43) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL5506611 | 0.70 | PDE4A (0.40) | PDE4APDE4DPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831227-A2 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS | Glenmark Pharmaceuticals S.A. (CH) | 2007-09-12 | — | — | EP | claimed |
| WO-2006064355-A2 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS | GLENMARK PHARMACEUTICALS S.A. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1831227-A2 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS | Glenmark Pharmaceuticals S.A. (CH) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006064355-A2 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS | GLENMARK PHARMACEUTICALS S.A. (US) | 2006-06-22 | — | — | WO | disclosed |