Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 14/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 14/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5501605 | 0.86 | MAPT (0.40) | PDE4APDE4BPDE4CPDE4DTDP1 | |
| SCHEMBL5506611 | 0.86 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DMAPT | |
| SCHEMBL5500958 | 0.84 | LMNA (0.36) | CA1CA2KDM4ESMN1; SMN2CLCN2 | |
| SCHEMBL74251 | 0.76 | KDM4E (0.39) | PDE4APDE4BPDE4CPDE4DTDP1 | |
| SCHEMBL3874282 | 0.76 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DTDP1 | |
| SCHEMBL73651 | 0.75 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DTDP1 | |
| SCHEMBL74507 | 0.74 | ALDH1A1 (0.47) | PDE4APDE4BPDE4CPDE4DTDP1 | |
| SCHEMBL73650 | 0.72 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DMGAM | |
| SCHEMBL5507780 | 0.71 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL74643 | 0.70 | MAPT (0.41) | PDE4APDE4BPDE4CPDE4DTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831227-A2 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS | Glenmark Pharmaceuticals S.A. (CH) | 2007-09-12 | — | — | EP | claimed |
| WO-2006064355-A2 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS | GLENMARK PHARMACEUTICALS S.A. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1831227-A2 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS | Glenmark Pharmaceuticals S.A. (CH) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006064355-A2 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS | GLENMARK PHARMACEUTICALS S.A. (US) | 2006-06-22 | — | — | WO | disclosed |