Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | GPR183 | P32249 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.33 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5508907 | 0.86 | FLT3 (0.46) | FLT3GPR183ALOX15ARMEN1 | |
| SCHEMBL5508886 | 0.84 | FLT3 (0.48) | FLT3ARCNR2IDO1 | |
| SCHEMBL5510077 | 0.74 | KDM4E (0.56) | FLT3CNR2MEN1KMT2AHRH4 | |
| SCHEMBL8267962 | 0.70 | HSD11B1 (0.40) | FLT3GPR183ARCNR2IDO1 | |
| SCHEMBL22013201 | 0.69 | FLT3 (0.55) | FLT3ARMEN1KMT2ARXFP1 | |
| SCHEMBL29988822 | 0.68 | CNR2 (0.65) | FLT3CNR2HRH4IDO1PDGFRB | |
| SCHEMBL5504683 | 0.68 | GPR183 (0.45) | FLT3GPR183ALOX15MEN1KMT2A | |
| SCHEMBL5509098 | 0.67 | FLT3 (0.65) | FLT3MEN1KMT2APDGFRB | |
| SCHEMBL5507378 | 0.64 | FLT3 (0.56) | FLT3CNR2HRH4PDGFRB | |
| SCHEMBL5507170 | 0.64 | PDGFRB (0.62) | FLT3MEN1KMT2AHRH4PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804781-A1 | NOVEL CYCLIC AND ACYCLIC PROPENONES FOR TREATING CNS DISORDERS | Merz Pharma GmbH & Co.KGaA (DE) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006037996-A1 | NOVEL CYCLIC AND ACYCLIC PROPENONES FOR TREATING CNS DISORDERS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2006-04-13 | — | — | WO | disclosed |