Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.60 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.60 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.39 |
| ▸ | INMT | O95050 | 1/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.35 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7551164 | 0.97 | TSHR (0.64) | TSHRTP53EGLN1EGLN3CA5A | |
| Fumaric Acid SCHEMBL18224111 | 0.97 | TSHR (0.64) | TSHRTP53EGLN1EGLN3CA5A | |
| Fumaric Acid SCHEMBL16914549 | 0.97 | TSHR (0.64) | TSHRTP53EGLN1EGLN3CA5A | |
| Maleic Acid SCHEMBL11768683 | 0.97 | TSHR (0.64) | TSHRTP53EGLN1EGLN3CA5A | |
| Fumaric Acid SCHEMBL15055651 | 0.93 | TSHR (0.60) | TSHRTP53EGLN1EGLN3CA5A | |
| Fumaric Acid SCHEMBL6057963 | 0.93 | TSHR (0.60) | TSHRTP53EGLN1EGLN3CA5A | |
| Fumaric Acid SCHEMBL6095324 | 0.93 | TSHR (0.69) | TSHRTP53EGLN1EGLN3CA5A | |
| Fumaric Acid SCHEMBL6095338 | 0.93 | TSHR (0.69) | TSHRTP53EGLN1EGLN3CA5A | |
| Maleic Acid SCHEMBL11860272 | 0.93 | TSHR (0.69) | TSHRTP53EGLN1EGLN3CA5A | |
| Fumaric Acid SCHEMBL9813915 | 0.90 | TSHR (0.64) | TSHRTP53EGLN1EGLN3CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791441-A1 | MINERAL FEED SUPPLEMENT | CAN TECHNOLOGIES, INC. (US) | 2007-06-06 | — | — | EP | disclosed |
| WO-2006034098-A1 | MINERAL FEED SUPPLEMENT | CAN TECHNOLOGIES, INC. (US) | 2006-03-30 | — | — | WO | disclosed |