SCHEMBL5510149

SCHEMBL5510149

Nc1cc(F)c(F)c2c(N)cccc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.42
CYP3A4 P08684 5/20 0.42
HPGD P15428 3/20 0.42
TSHR P16473 3/20 0.42
TDP1 Q9NUW8 3/20 0.42
HSD17B10 Q99714 2/20 0.42
KDM4E B2RXH2 3/20 0.39
MAPT P10636 3/20 0.39
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
LMNA P02545 1/20 0.39
GAA P10253 1/20 0.39
KEAP1 Q14145 3/20 0.37
CRHBP P24387 2/20 0.36
CRHR2 Q13324 2/20 0.36
NFE2L2 Q16236 2/20 0.36
NR4A2 P43354 2/20 0.34
PARP1 P09874 2/20 0.32
CASP1 P29466 2/20 0.32
CASP7 P55210 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5522970 0.82 TSHR (0.38) ALDH1A1CYP3A4HPGDTSHRTDP1
SCHEMBL5508794 0.78 ALDH1A1 (0.34) ALDH1A1CYP3A4HPGDTSHRTDP1
SCHEMBL27478351 0.76 ALDH1A1 (0.48) ALDH1A1CYP3A4HPGDTSHRTDP1
SCHEMBL5508816 0.74 ALDH1A1 (0.52) ALDH1A1CYP3A4HPGDTSHRTDP1
SCHEMBL5511698 0.72 ALDH1A1 (0.44) ALDH1A1CYP3A4HPGDTSHRTDP1
SCHEMBL21554193 0.71 CYP3A4 (0.48) ALDH1A1CYP3A4HPGDTSHRTDP1
SCHEMBL5517966 0.71 ALDH1A1 (0.48) ALDH1A1CYP3A4HPGDTSHRTDP1
SCHEMBL21840833 0.71 ALDH1A1 (0.42) ALDH1A1CYP3A4HPGDTSHRTDP1
SCHEMBL5516172 0.71 CYP3A4 (0.42) ALDH1A1CYP3A4HPGDTSHRTDP1
SCHEMBL5513559 0.69 ALDH1A1 (0.41) ALDH1A1CYP3A4HPGDTSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7208559-B2 Ethylened polymer and molded object obtained therefrom MITSUI CHEMICALS, INC. (JP) 2007-04-24 US disclosed
US-20060135712-A1 Ethylened polymer and molded object obtained therefrom MITSUI CHEMICALS, INC. (JP) 2006-06-22 US disclosed