Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7164821 | 0.79 | PTPN1 (0.65) | PTPN2PTPN1ALOX15 | |
| SCHEMBL16525901 | 0.76 | PTPN1 (0.61) | PTPN2PTPN1 | |
| SCHEMBL5503555 | 0.74 | CA1 (0.42) | L3MBTL1PTPN2PTPN1SMN1; SMN2MAPT | |
| SCHEMBL5508634 | 0.67 | ALDH1A1 (0.42) | ABCB11L3MBTL1PTPN2PTPN1SMN1; SMN2 | |
| SCHEMBL10614794 | 0.65 | CYP2C19 (0.39) | PTPN2PTPN1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL3735798 | 0.65 | PTPN5 (0.40) | PTPN1MAPT | |
| SCHEMBL3737657 | 0.65 | PTPN1 (0.45) | PTPN2PTPN1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL3800719 | 0.65 | PTPN1 (0.38) | PTPN2PTPN1 | |
| SCHEMBL5266952 | 0.65 | HPGD (0.43) | KDM4E | |
| SCHEMBL21348905 | 0.64 | PPARG (0.45) | KMT2AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786421-A2 | OXYGEN/NITROGEN HETEROCYCLE INHIBITORS OF TYROSINE PHOSPHATASES | Cengent Therapeutics, Inc. (US) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006017124-A2 | OXYGEN/NITROGEN HETEROCYCLE INHIBITORS OF TYROSINE PHOSPHATASES | CENGENT THERAPEUTICS, INC. (US) | 2006-02-16 | — | — | WO | disclosed |