⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL551051 | 0.98 | — | — | |
| SCHEMBL15654169 | 0.70 | — | — | |
| SCHEMBL19139397 | 0.67 | ALDH1A1 (0.33) | — | |
| SCHEMBL815726 | 0.60 | — | — | |
| SCHEMBL953550 | 0.60 | — | — | |
| SCHEMBL5695351 | 0.58 | — | — | |
| SCHEMBL6584212 | 0.58 | — | — | |
| SCHEMBL7739600 | 0.58 | — | — | |
| SCHEMBL7738671 | 0.58 | — | — | |
| SCHEMBL6347518 | 0.58 | ALDH1A1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 67 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11964943-B2 | 3,5-diarylidenyl-n-substituted-piperid-4-one-derived inhibitors of Stat3 pathway activity and uses thereof | KIAKOS KONSTANTINOS (AT) | 2024-04-23 | — | — | US | disclosed |
| US-20200399220-A1 | 3,5-DIARYLIDENYL-N-SUBSTITUTED-PIPERID-4-ONE-DERIVED INHIBITORS OF STAT3 PATHWAY ACTIVITY AND USES THEREOF | KIAKOS KONSTANTINOS (AT) | 2020-12-24 | — | — | US | disclosed |
| WO-2019097080-A9 | 3,5-DIARYLIDENYL-N-SUBSTITUTED-PIPERID-4-ONE-DERIVED INHIBITORS OF STAT3 PATHWAY ACITIVTY AND USES THEROF | KIAKOS KONSTANTINOS (AT) | 2020-10-15 | — | — | WO | disclosed |
| US-20200148646-A1 | 6-SUBSTITUTED AND 7-SUBSTITUTED MORPHINAN ANALOGS AND THE USE THEREOF | PURDUE PHARMA LP (US) | 2020-05-14 | — | — | US | disclosed |
| US-10550088-B2 | 6-substituted and 7-substituted morphinan analogs and the use thereof | PURDUE PHARMA L.P. (US) | 2020-02-04 | — | — | US | disclosed |
| EP-3564240-A1 | PIPERIDINE INTERMEDIATES | Purdue Pharma L.P. (US) | 2019-11-06 | — | — | EP | disclosed |
| EP-3087078-B1 | 7-BETA-ALKYL ANALOGS OF ORVINOLS | PURDUE PHARMA LP (US) | 2019-05-15 | — | — | EP | disclosed |
| EP-2931729-B1 | BUPRENORPHINE ANALOGS AS OPIOD RECEPTOR MODULATORS | PURDUE PHARMA LP (US) | 2019-02-06 | — | — | EP | disclosed |
| US-10138207-B2 | Benzomorphan analogs and the use thereof | PURDUE PHARMA, L.P. (US) | 2018-11-27 | — | — | US | disclosed |
| EP-2788358-B1 | QUATERNIZED BUPRENORPHINE ANALOGS | PURDUE PHARMA LP (US) | 2018-08-29 | — | — | EP | disclosed |
| EP-2433936-A1 | Substituted-quinoxaline-type-piperidine compounds and the uses thereof | Purdue Pharma LP (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-2433935-A1 | Substituted-quinoxaline-type-piperidine compounds and the uses thereof | Purdue Pharma LP (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-2433937-A1 | Substituted-quinoxaline-type-piperidine compounds and the uses thereof | Purdue Pharma LP (US) | 2012-03-28 | — | — | EP | disclosed |
| US-8110602-B2 | Compounds comprising heterocyclic-substituted piperidine for treating pain | PURDUE PHARMA L.P. (US) | 2012-02-07 | — | — | US | disclosed |
| EP-2397477-A1 | Heterocyclic-substituted piperidine compounds and the uses thereof | Purdue Pharma LP (US) | 2011-12-21 | — | — | EP | disclosed |
| US-20110136846-A1 | Buprenorphine Analogs | PURDUE PHARMA L.P. (US) | 2011-06-09 | — | — | US | disclosed |
| EP-2280008-A2 | Heterocyclic-substituted piperidines as ORL-1 ligands | Purdue Pharma L.P. (US) | 2011-02-02 | — | — | EP | disclosed |
| EP-2076506-B1 | HETEROCYCLIC-SUBSTITUTED PIPERIDINES AS ORL-1 LIGANDS | PURDUE PHARMA LP (US) | 2010-09-22 | — | — | EP | disclosed |
| US-20100216726-A1 | Substituted-Quinoxaline-Type Piperidine Compounds and the Uses Thereof | PURDUE PHARMA L.P. (US) | 2010-08-26 | — | — | US | disclosed |
| US-20100022519-A1 | HETEROCYCLIC-SUBSTITUTED PIPERIDINE COMPOUNDS AND THE USES THEREOF | PURDUE PHARMA L.P. | 2010-01-28 | — | — | US | disclosed |