Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | PLAT | P00750 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3464845 | 0.81 | CHRNB2 (0.36) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL5503163 | 0.78 | CHRNB2 (0.43) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| SCHEMBL5506072 | 0.78 | — | — | |
| SCHEMBL4882863 | 0.74 | HTR2C (0.47) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL23130915 | 0.73 | HTR2C (0.49) | CHRNB2CHRNA4PLATNTRK1CSF1R | |
| SCHEMBL31649083 | 0.72 | KDM1A (0.38) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL31637119 | 0.72 | KDM1A (0.38) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL29180518 | 0.72 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL30801024 | 0.72 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNA4 | |
| SCHEMBL3924233 | 0.72 | PDE4B (0.48) | CHRNB2CHRNA4KDM1APLAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802601-A1 | AZASPIROALKENE AND AZAPIROALKANE COMPOUNDS WITH NICOTINIC CHOLINERGIC RECEPTOR ACTIVITY | Targacept, Inc. (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006034089-A1 | AZASPIROALKENE AND AZASPIROALKANE COMPOUNDS WITH NICOTINIC CHOLINERGIC RECEPTOR ACTIVITY | TARGACEPT, INC. (US) | 2006-03-30 | — | — | WO | disclosed |