Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | OTUD7B | Q6GQQ9 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | MERTK | Q12866 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699554 | 1.00 | HSD11B1 (0.38) | HSD11B1HCRTR2HCRTR1PRMT6OTUD7B | |
| SCHEMBL2699559 | 1.00 | HSD11B1 (0.38) | HSD11B1HCRTR2HCRTR1PRMT6OTUD7B | |
| SCHEMBL549743 | 1.00 | HSD11B1 (0.38) | HSD11B1HCRTR2HCRTR1PRMT6OTUD7B | |
| SCHEMBL551056 | 1.00 | HSD11B1 (0.38) | HSD11B1HCRTR2HCRTR1PRMT6OTUD7B | |
| SCHEMBL549742 | 1.00 | HSD11B1 (0.38) | HSD11B1HCRTR2HCRTR1PRMT6OTUD7B | |
| SCHEMBL2702427 | 0.88 | HSD11B1 (0.43) | HSD11B1 | |
| SCHEMBL550851 | 0.88 | HSD11B1 (0.43) | HSD11B1 | |
| SCHEMBL550850 | 0.88 | HSD11B1 (0.43) | HSD11B1 | |
| SCHEMBL2702428 | 0.88 | HSD11B1 (0.43) | HSD11B1 | |
| SCHEMBL549793 | 0.85 | NOTUM (0.43) | HSD11B1HCRTR2HCRTR1DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |