Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 20/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.41 |
| ▸ | PDE1A | P54750 | 11/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 11/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 11/20 | 0.41 |
| ▸ | PDE7B | Q9NP56 | 4/20 | 0.41 |
| ▸ | PDE5A | O76074 | 4/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4246900 | 0.89 | PDE7A (0.53) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL4246621 | 0.78 | PDE7A (0.55) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL4246426 | 0.76 | PDE7A (0.71) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL5104838 | 0.71 | PDE7A (0.55) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL5116939 | 0.70 | PDE7A (0.72) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL5115313 | 0.69 | PDE7A (0.57) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL2680154 | 0.66 | PDE7A (0.55) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL3952083 | 0.66 | PDE7A (0.50) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL5511192 | 0.65 | PDE7A (0.61) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL291618 | 0.64 | PDE7A (0.53) | PDE7APDE4DPDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1855686-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN | Pfizer Limited (GB) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006092691-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN | PFIZER LIMITED (GB) | 2006-09-08 | — | — | WO | disclosed |