Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 19/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 16/20 | 0.61 |
| ▸ | PDE1A | P54750 | 12/20 | 0.61 |
| ▸ | PDE1B | Q01064 | 12/20 | 0.61 |
| ▸ | PDE1C | Q14123 | 12/20 | 0.61 |
| ▸ | PDE7B | Q9NP56 | 4/20 | 0.54 |
| ▸ | PDE5A | O76074 | 5/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4253220 | 0.90 | PDE7A (0.75) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL5109597 | 0.77 | PDE7A (0.82) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL4257975 | 0.75 | PDE7A (0.84) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL5115877 | 0.71 | PDE7A (1.00) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL5113961 | 0.69 | PDE7A (0.79) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL20694154 | 0.68 | PDE7A (0.78) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL5510700 | 0.65 | PDE7A (0.41) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL20649723 | 0.65 | PDE7B (1.00) | PDE7B | |
| SCHEMBL8245267 | 0.65 | PDE7A (1.00) | PDE7APDE4DPDE1APDE1BPDE1C | |
| SCHEMBL299266 | 0.63 | PDE7A (0.42) | PDE7APDE4DPDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1855686-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN | Pfizer Limited (GB) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006092691-A1 | USE OF PDE7 INHIBITORS FOR THE TREATMENT OF NEUROPATHIC PAIN | PFIZER LIMITED (GB) | 2006-09-08 | — | — | WO | disclosed |
| WO-2006092692-A1 | USE OF COMBINATIONS OF PDE7 INHIBITORS AND ALPHA-2-DELTY LIGANDS FOR THE TREATMENT OF NEUROPATHIC PAIN | PFIZER LIMITED (GB) | 2006-09-08 | — | — | WO | disclosed |