Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK4 | Q16654 | 1/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 8/20 | 0.48 |
| ▸ | GRM5 | P41594 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL282496 | 0.92 | PDK4 (0.50) | PDK4GRM1GRM5ALDH1A1LMNA | |
| SCHEMBL6365955 | 0.88 | PDK4 (0.52) | PDK4GRM1GRM5ALDH1A1LMNA | |
| SCHEMBL17054290 | 0.87 | PDK4 (0.51) | PDK4GRM1GRM5ALDH1A1LMNA | |
| SCHEMBL31630903 | 0.87 | PDK4 (0.51) | PDK4GRM1GRM5ALDH1A1LMNA | |
| SCHEMBL5004734 | 0.87 | PDK4 (0.51) | PDK4GRM1GRM5ALDH1A1LMNA | |
| SCHEMBL5511826 | 0.86 | QDPR (0.43) | ALDH1A1LMNAMAPT | |
| SCHEMBL5511829 | 0.86 | QDPR (0.43) | ALDH1A1LMNAMAPT | |
| SCHEMBL522085 | 0.85 | PDK4 (0.52) | PDK4GRM1GRM5ALDH1A1LMNA | |
| SCHEMBL29864873 | 0.85 | PDK4 (0.52) | PDK4GRM1GRM5ALDH1A1LMNA | |
| SCHEMBL10036179 | 0.84 | PDK4 (0.51) | PDK4GRM1GRM5ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199135-B2 | Substituted alkyl amido piperidines | H. LUNDBECK A/S (DK) | 2007-04-03 | — | — | US | disclosed |
| US-20060217418-A1 | Substituted alkyl amido piperidines | H. LUNDBECK A/S (DK) | 2006-09-28 | — | — | US | disclosed |
| US-20060084649-A9 | Substituted alkyl amido piperidines | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2006-04-20 | — | — | US | disclosed |
| US-20040186103-A1 | Substituted alkyl amido piperidines | SYNAPTIC PHARMACEUTICAL CORPORATION | 2004-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084649-A9 | Substituted alkyl amido piperidines | MCHR1, MCHR2, MC1R | PDK4 1779/4885GRM1 88/4885GRM5 180/4885 |
| US-20060217418-A1 | Substituted alkyl amido piperidines | MCHR1, MCHR2, MC1R | PDK4 1779/4885GRM1 88/4885GRM5 180/4885 |
| US-20040186103-A1 | Substituted alkyl amido piperidines | MCHR1, MCHR2, MC1R | PDK4 1779/4885GRM1 88/4885GRM5 180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.