Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 16/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 15/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | GHSR | Q92847 | 1/20 | 0.48 |
| ▸ | UBE2M | P61081 | 2/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485498 | 0.85 | SLC6A2 (0.50) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL5072308 | 0.84 | SLC6A4 (0.76) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL5512041 | 0.82 | SLC6A2 (0.63) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL5506157 | 0.81 | SLC6A2 (0.64) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4635761 | 0.78 | SLC6A2 (0.62) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL25194484 | 0.78 | GHSR (0.53) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL25265564 | 0.78 | GHSR (0.53) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL5888071 | 0.72 | SLC6A2 (0.45) | SLC6A4SLC6A2SLC6A3KCNH2UBE2M | |
| SCHEMBL5511572 | 0.72 | SLC6A2 (0.65) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 | |
| SCHEMBL4634797 | 0.72 | PDK2 (0.44) | SLC6A4SLC6A2SLC6A3CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828122-A2 | N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALIN RE-UPTAKE INHIBITORS | Pfizer Limited (GB) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006064351-A2 | N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALIN RE-UPTAKE INHIBITORS | PFIZER LIMITED (GB) | 2006-06-22 | — | — | WO | disclosed |