Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene Glycol SCHEMBL1412702 | 0.92 | TSHR (0.64) | TSHRMAPK1SMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL551254 | 0.92 | TSHR (0.75) | TSHRMAPK1SMN1; SMN2ALDH1A1TDP1 | |
| Alcohol SCHEMBL150777 | 0.83 | SMN1; SMN2 (0.58) | TSHRMAPK1SMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL21758297 | 0.82 | TSHR (0.61) | TSHRMAPK1SMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL4461926 | 0.81 | TSHR (0.59) | TSHRMAPK1SMN1; SMN2ALDH1A1TDP1 | |
| Propane SCHEMBL3297482 | 0.81 | TSHR (0.60) | TSHRMAPK1SMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL1069813 | 0.80 | TSHR (0.77) | TSHRMAPK1SMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL1471724 | 0.80 | TSHR (0.64) | TSHRMAPK1SMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL17965675 | 0.80 | TSHR (0.64) | TSHRMAPK1SMN1; SMN2ALDH1A1TDP1 | |
| SCHEMBL1192364 | 0.79 | TSHR (0.69) | TSHRMAPK1SMN1; SMN2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1652891-B1 | CURABLE RESIN COMPOSITION AND COLD-SETTING ADHESIVE | KONISHI CO LTD (JP) | 2012-06-13 | — | — | EP | disclosed |
| US-8110645-B2 | Curable resin composition | KONISHI CO., LTD. (JP) | 2012-02-07 | — | — | US | disclosed |
| CN-100590149-C | Curable resin composition and moisture-curing adhesive composition | KONISHI CO LTD | 2010-02-17 | — | — | CN | disclosed |
| US-20090264602-A1 | Curable Resin Composition and Cold Setting Adhesive | KONISHI CO., LTD. (JP) | 2009-10-22 | — | — | US | disclosed |
| US-7576167-B2 | Curable resin composition | KONISHI CO., LTD. (JP) | 2009-08-18 | — | — | US | disclosed |
| US-20060189736-A1 | Curable resin composition and cold-setting adhesive | KONISHI CO., LTD. (JP) | 2006-08-24 | — | — | US | disclosed |
| CN-1823139-A | Curable resin composition and moisture-curing adhesive composition | KONISHI CO LTD (JP) | 2006-08-23 | — | — | CN | disclosed |
| EP-1652891-A1 | CURABLE RESIN COMPOSITION AND COLD-SETTING ADHESIVE | KONISHI CO., LTD. (JP) | 2006-05-03 | — | — | EP | disclosed |