Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL549640 | 1.00 | HSD11B1 (0.38) | HSD11B1HTR1ARIPK1GPBAR1USP2 | |
| SCHEMBL549639 | 1.00 | HSD11B1 (0.38) | HSD11B1HTR1ARIPK1GPBAR1USP2 | |
| SCHEMBL551296 | 1.00 | HSD11B1 (0.38) | HSD11B1HTR1ARIPK1GPBAR1USP2 | |
| SCHEMBL2701235 | 1.00 | HSD11B1 (0.38) | HSD11B1HTR1ARIPK1GPBAR1USP2 | |
| SCHEMBL551358 | 1.00 | HSD11B1 (0.38) | HSD11B1HTR1ARIPK1GPBAR1USP2 | |
| SCHEMBL2699332 | 1.00 | HSD11B1 (0.38) | HSD11B1HTR1ARIPK1GPBAR1USP2 | |
| SCHEMBL2699330 | 1.00 | HSD11B1 (0.38) | HSD11B1HTR1ARIPK1GPBAR1USP2 | |
| SCHEMBL550495 | 1.00 | HSD11B1 (0.38) | HSD11B1HTR1ARIPK1GPBAR1USP2 | |
| SCHEMBL5632652 | 0.89 | HSD11B1 (0.39) | HSD11B1HTR1ARIPK1SIGMAR1 | |
| SCHEMBL4722160 | 0.89 | HSD11B1 (0.39) | HSD11B1HTR1ARIPK1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |