Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2697853 | 1.00 | NPC1 (0.40) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL549346 | 1.00 | NPC1 (0.40) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL551388 | 1.00 | NPC1 (0.40) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL2697855 | 1.00 | NPC1 (0.40) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL549345 | 1.00 | NPC1 (0.40) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL551743 | 0.98 | ALDH1A1 (0.41) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL2701931 | 0.98 | ALDH1A1 (0.41) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL551742 | 0.98 | ALDH1A1 (0.41) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL549275 | 0.98 | ALDH1A1 (0.41) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL549274 | 0.98 | ALDH1A1 (0.41) | NPC1RAB9AALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |
| EP-1812005-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006053024-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |