Sugi Predict

Sugi Predict / Compounds / SCHEMBL5515995

SCHEMBL5515995

SCHEMBL5515995

O=C(Nc1cccc(C2CCN(CCCNC(=O)C3(c4ccc(F)cc4Cl)CCCC3)CC2)c1)C1CC1

nearest known ligand 0.52

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ MCHR1 Q99705 6/20 0.52
▸ ACKR3 P25106 1/20 0.43
▸ DRD2 P14416 1/20 0.43
▸ NPY1R P25929 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5514892 0.90 DRD2 (0.54) MCHR1DRD2
SCHEMBL5511810 0.89 ACKR3 (0.54) MCHR1ACKR3DRD2NPY1R
SCHEMBL5517902 0.89 DRD2 (0.54) MCHR1DRD2
SCHEMBL5888200 0.88 MCHR1 (0.57) MCHR1
SCHEMBL5513896 0.87 MCHR1 (0.45) MCHR1DRD2NPY1R
SCHEMBL4794463 0.85 DRD2 (0.51) MCHR1ACKR3DRD2
SCHEMBL5513362 0.82 DRD2 (0.53) MCHR1ACKR3DRD2
SCHEMBL5515324 0.80 KCNH2 (0.49) MCHR1
SCHEMBL5888176 0.80 MCHR1 (0.57) MCHR1DRD2
SCHEMBL5508596 0.79 KCNH2 (0.51) MCHR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7199135-B2 Substituted alkyl amido piperidines H. LUNDBECK A/S (DK) 2007-04-03 — — US disclosed
US-7199135-B2 Substituted alkyl amido piperidines H. LUNDBECK A/S (DK) 2007-04-03 — — US disclosed
US-7199135-B2 Substituted alkyl amido piperidines H. LUNDBECK A/S (DK) 2007-04-03 — — US disclosed
US-20060217418-A1 Substituted alkyl amido piperidines H. LUNDBECK A/S (DK) 2006-09-28 — — US disclosed
US-7105544-B2 Substituted alkyl amido piperidines SYNAPTIC PHARMACEUTICAL CORPORATION (US) 2006-09-12 — — US disclosed
US-20060084649-A9 Substituted alkyl amido piperidines SYNAPTIC PHARMACEUTICAL CORPORATION (US) 2006-04-20 — — US disclosed
US-20060041139-A9 SUBSTITUTED ALKYL AMIDO PIPERIDINES H. LUNDBECK A/S (DK) 2006-02-23 — — US disclosed
US-20040186103-A1 Substituted alkyl amido piperidines SYNAPTIC PHARMACEUTICAL CORPORATION 2004-09-23 — — US disclosed
US-20040073036-A1 Substituted alkyl amido piperidines SYNAPTIC PHARMACEUTICAL CORPORATION 2004-04-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040073036-A1 Substituted alkyl amido piperidines MCHR1, MCHR2, MC1R MCHR1 1/4885ACKR3 176/4885DRD2 74/4885
US-20060084649-A9 Substituted alkyl amido piperidines MCHR1, MCHR2, MC1R MCHR1 1/4885ACKR3 176/4885DRD2 74/4885
US-20060041139-A9 SUBSTITUTED ALKYL AMIDO PIPERIDINES MCHR1, MCHR2, MC1R MCHR1 1/4885ACKR3 176/4885DRD2 74/4885
US-20060217418-A1 Substituted alkyl amido piperidines MCHR1, MCHR2, MC1R MCHR1 1/4885ACKR3 176/4885DRD2 74/4885
US-20040186103-A1 Substituted alkyl amido piperidines MCHR1, MCHR2, MC1R MCHR1 1/4885ACKR3 176/4885DRD2 74/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.