Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 3/20 | 0.66 |
| ▸ | IKBKB | O14920 | 1/20 | 0.66 |
| ▸ | CHUK | O15111 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MAP2 | P11137 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.43 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5531760 | 0.90 | LIMK1 (0.64) | LIMK1IKBKBCHUKALDH1A1KDM4E | |
| SCHEMBL5529444 | 0.87 | LIMK1 (0.61) | LIMK1IKBKBCHUKALDH1A1KDM4E | |
| SCHEMBL8240403 | 0.83 | KDM4E (0.48) | LIMK1IKBKBCHUKALDH1A1KDM4E | |
| SCHEMBL13605637 | 0.81 | KDM4E (0.52) | LIMK1IKBKBCHUKALDH1A1KDM4E | |
| SCHEMBL5648903 | 0.81 | KDM4E (0.53) | ALDH1A1KDM4EMEN1KMT2ANPC1 | |
| SCHEMBL13605639 | 0.80 | PADI4 (0.49) | ALDH1A1KDM4EKMT2ANPC1RAB9A | |
| SCHEMBL4356230 | 0.80 | IKBKB (1.00) | LIMK1IKBKBCHUKALDH1A1KDM4E | |
| SCHEMBL4533208 | 0.78 | KDM4E (0.49) | LIMK1IKBKBCHUKALDH1A1KDM4E | |
| SCHEMBL20723069 | 0.78 | LIMK1 (0.69) | LIMK1IKBKBCHUKALDH1A1KDM4E | |
| SCHEMBL11341595 | 0.78 | LIMK1 (0.69) | LIMK1IKBKBCHUKALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070082880-A1 | Thieno [2,3-B] pyridine-5-carbonitriles as protein kinase inhibitors | WYETH | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082880-A1 | Thieno [2,3-B] pyridine-5-carbonitriles as protein kinase inhibitors | MAP4K2, CNKSR1, MAP3K1 | LIMK1 1108/4885IKBKB 243/4885CHUK 48/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.