Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TERT | O14746 | 15/20 | 0.39 |
| ▸ | F2R | P25116 | 1/20 | 0.34 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30786221 | 1.00 | CCR1 (0.44) | CCR1ALDH1A1TERTF2RSLC10A1 | |
| SCHEMBL6273480 | 0.87 | ALDH1A1 (0.36) | ALDH1A1F2R | |
| SCHEMBL303150 | 0.87 | CCR1 (0.55) | CCR1ALDH1A1TERT | |
| Hydrochloric Acid SCHEMBL27613798 | 0.85 | CCR1 (0.52) | CCR1ALDH1A1TERT | |
| SCHEMBL29476108 | 0.75 | CCR1 (0.48) | CCR1ALDH1A1TERT | |
| SCHEMBL28907909 | 0.75 | CCR1 (0.40) | CCR1ALDH1A1 | |
| SCHEMBL2151538 | 0.75 | CCR1 (0.48) | CCR1ALDH1A1TERT | |
| SCHEMBL30064333 | 0.73 | CCR1 (0.39) | CCR1ALDH1A1 | |
| SCHEMBL16289246 | 0.73 | — | — | |
| SCHEMBL13474826 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103304572-A | 3-cyanoquinoline compound as well as pharmaceutical composition and application thereof | SHANGHAI PHARMACEUTICAL GROUP CO LTD | 2013-09-18 | — | — | CN | disclosed |
| US-7256186-B2 | Gamma secretase inhibitors | SCHERING CORPORATION (US) | 2007-08-14 | — | — | US | disclosed |
| US-7208602-B2 | Gamma secretase inhibitors | SCHERING CORPORATION (US) | 2007-04-24 | — | — | US | disclosed |
| EP-1663975-A1 | NOVEL GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2006-06-07 | — | — | EP | disclosed |
| US-20060100427-A1 | Novel Gamma Secretase inhibitors | SCHERING CORPORATION AND PHARMACOPEIA, INC. | 2006-05-11 | — | — | US | disclosed |
| US-20050085506-A1 | Novel gamma secretase inhibitors | SCHERING-PLOUGH CORPORATION AND PHARMACOPEIA, INC. | 2005-04-21 | — | — | US | disclosed |
| WO-2005028440-A1 | NOVEL GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2005-03-31 | — | — | WO | disclosed |
| EP-1472223-A1 | GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2004-11-03 | — | — | EP | disclosed |
| US-20040171614-A1 | Novel gamma secretase inhibitors | SCHERING-PLOUGH CORPORATION | 2004-09-02 | — | — | US | disclosed |
| US-20040048848-A1 | Novel gamma secretase inhibitors | SCHERING-PLOUGH CORPORATION AND PHARMACOPEIA, INC. | 2004-03-11 | — | — | US | disclosed |
| WO-2003066592-A1 | GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171614-A1 | Novel gamma secretase inhibitors | BACE1, BACE2, APP | CCR1 482/4885ALDH1A1 4012/4885TERT 1683/4885 |
| US-20040048848-A1 | Novel gamma secretase inhibitors | BACE1, BACE2, PSEN1 | CCR1 3177/4885ALDH1A1 1953/4885TERT 874/4885 |
| US-20060100427-A1 | Novel Gamma Secretase inhibitors | BACE1, BACE2, PSEN1 | CCR1 3020/4885ALDH1A1 1610/4885TERT 790/4885 |
| US-20050085506-A1 | Novel gamma secretase inhibitors | BACE1, BACE2, APP | CCR1 718/4885ALDH1A1 2742/4885TERT 1516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.